Dialysable Peptide as the Causative Factor in Experimental ‘Allergic’ Encephalomyelitis

nerve growth factor prevents demyelination, cell death and progression of the disease in experimental allergic encephalomyelitis

experimental allergic encephalomyelitis (eae), a demyelinating disease induced in the animals parallels multiple sclerosis in human in several aspects, provides a useful model to investigate multiple sclerosis. in this study, we have therefore used this model to study functions of nerve growth factor (ngf) in eae. ngf with considerable effects on neuron survival, proliferation and differentiati...

Metabolomics approaches in experimental allergic encephalomyelitis.

A myelin basic protein (MBP)-induced experimental allergic encephalomyelitis (EAE) involves paraplegia due to a reversible thoracolumbar spinal cord impairment. The aims of this study were thus to find significant metabolic biomarkers of inflammation and identify the site of inflammation in the central nervous system (CNS) during the acute signs in of the disease using metabolomics. All the EAE...

Experimental Allergic Encephalomyelitis in Oxygen Immunosuppression : Modification

Myelin-binding antibodies in experimental "allergic" encephalomyelitis.

Antibodies with a specificity for myelin, as demonstrated by immunofluorescence, are present in the sera of rabbits injected with spinal cord. These antibodies react with both adult rabbit and human spinal cord but not with unmyelinated areas of neonatal human spinal cord.

AGE proteins as a causative factor in Alzheimer's Disease

The reaction between reducing sugars and protein free amines, known as the Maillar reaction results in the formation of advanced glycation endproducts (AGEs). AGE modification changes the structure of proteins to amyloid cross-beta structure. These protein structures can activate receptors known as RAGE on glial cells (microglia and astrocytes), and induce the expression of inducible nitric oxi...